The Laboratory of Natural Bioregulators

Head: IVANOVA Raisa, PhD in technical science, associate professor
Laboratory of Natural Bioregulators was created by Professor CHINTEA Pavel in 1990













Laboratory staff:

1.    MAȘCENKO Natalia, PhD in chemistry, research coordinator
2.    ELISOVEȚCAIA Dina, PhD in biology, research coordinator
3.    BOROVSKAIA Alla, researcher
4.    POPOVSCHI Ecaterina, chemist
5.    LUȚCAN Elena, biologist
6.    ȚAPUCHEVICI Valentina, laboratory technician

Research directions:

  • Identification of plant sources to obtain of biologically active substances (growth regulators, antioxidants, biopesticides, antiviral substances) and natural food coloring;
  • Obtaining extracts containing the biologically active substances, purification and determination of the active principles of extracts or preparations in various preparative forms (liquid or dry extract, polymer bioconjugate, essential oils);
  • In vitro and in vivo testing of biological activities of obtained extracts and isolated compounds as plant growth regulators, antioxidants and biopesticides;
  • Development of procedures for obtaining of new natural preparations with biological activity and their application in ecological agriculture, silviculture and food industry.

Research materials:

Linaria spp., Veronica spp., Verbascum spp., Carthamus tinctorius, Juniperus spp., Fagus sylvatica, Juglans regia, Phytolacca americana and other plant species as sources of biologically active substances with perspective of utilization in agriculture, silviculture and food industry.

National projects:

2020-2023 “Determining the parameters that characterize the resistance of plants with the different level of organization to the action of extreme temperatures in order to reduce the effects of climate change”, project manager DASCALIUC A., Professor.
2015-2019 “Study of chemical structure and biological activity of bioregulators of vegetative origin, both native and immobilized on polymeric supports, for utilization in plant growing technologies”, project manager IVANOVA R, PhD.

International projects:
2019-2020 „SAVE BEES: Save endangered bees to improve nutrition, health and life quality of human”, (”), project coordinator BRINDZA J., PhD (Slovakia).
2017-2018 “Neglected and Underutilized Species in the Socio-Economic Aspects of Rural Development”, (, project coordinator BRINDZA J, PhD (Slovakia).
Bilateral cooperation Slovakia – Moldova
2019-2020 “Biopesticides for pests’ management in organic farming”, project manager ELISOVEȚCAIA D., PhD.
Program “Commune initiative of research and development” ASM &STCU
2016-2018 STCU 6093 “Biological, chemical and biotechnological researches of Carthamus spp. plants” project manager IVANOVA R., PhD.

Relevant results:

The preparations MOLDSTIM, ECOSTIM, PAVSTIM and MESTIM have been elaborated, standardized, certified and implemented in plant cultivation technologies as regulators of plant growth and development. The preparations are harmless to the environment, greatly increase crop productivity and plant tolerance to adverse weather conditions and disease.
Recommendations have been developed and published on the application of natural growth regulators in the cultivation technology of cereals and vegetables.

Innovative aspects:

1.    MAȘCENCO, N.; LUPASCU, G.; GUREV, A.; BARBA, A.; GORICIOI, E.; GAVZER, S. Procedeu de tratare a grâului de toamnă contra Fuzarium oxysporum. Brevet de invenție MD 819. 2015-05-31
2.    IVANOVA, R.; TATAROV, P. Procedeu de obținere a compușilor antioxidanți din pielița de miez de nucă (Juglans regia L.). Brevet de inventive MD 835. 2015-07-31.
3.    BOROVSKAIA, A.; POLTAVCENCO, I.; MAȘCENCO, N.; IVANOVA, R.; BOTNARI, V. Procedeu de tratare a semințelor de ceapă comună înainte de semănat. Brevet de invenție MD 893. 2015-11-30.
4.    BOROVSKAIA, A.; MAŞCENCO, N.; BOTNARI, V.; GUMANIUC, A.; VASILACHI, Iu.; POLTAVCENCO, I. Procedeu de tratare a semințelor de morcov înainte de semănat. Brevet de invenție MD 922, 2016.04.30.
5.    MAŞCENCO, N.;  GUREV, A.; COZARI, E.; CRIVENCOV, L.; BESPALICO, L.; BALASOVA, I.; CHIRILOV, E. Procedeu de tratare a semințelor de salata verde. Brevet de invenție MD 957, 2016.05.31.
6.    GRADINAR, D.; BOROVSKAIA, A.; MAȘCENCO, N.; BOTNARI, V.; GUMANIUC, A.; CIUMAC, P. Procedeu de tratare a semințelor de ceapă comună înainte de semănat. Brevet de invenție MD-1188, 2017.09.30.
7.    ŞUBINA, V.; MAȘCENCO, N.; BOROVSKAIA, A.; GUREV, A.; ROŞCA, I. Efectul fungicidic al  glicozidelor  din  Veronica officinalis L.  Brevet de invenție MD-1192, 2017.09.30.
8.    ELISOVETCAIA, D.; BOROVSKAIA, A.; IVANOVA, R.; MAŞCENCO, N.; DOROŞENCO, V.; VOINEAC, V. Procedeu de tratare a cartofului. Brevet de invenție MD-1324, 2019.03. 31.

Relevant publications:

1.    ИВАНОВА, Р.; ЕЛИСОВЕЦКАЯ, Д. Биологические пестициды – растения для защиты растений. Координатор Я. Бриндза. Нитра: Изд. Словацкий аграрный университет в Нитре, Словакия, 2018. 126с. ISBN: 978-80-552-1854-0, doi:
2.    IVANOVA, R.; SMEREA, S. Safflower yield response to irrigation and gamma irradiation. Agriculture and forestry. 2019, 65 (Issue 1), 29-38. eISSN 1800-6492; pISSN 0554-5579. doi 10.17707/AgricultForest.65.1.03 (IF: 1.2545)
3.    ELISOVETCAIA D.S., BRINDZA J. Effect of secondary metabolites Juniperus sabina L. (Cupressaceae) on the survival and nutrition of caterpillars Galleria mellonella L. (Pyralidae). Contemporary Problems of Ecology, 2018, Vol. 11, No. 6, pp. 594–603 (IF:0.595).
4.    MASCENKO, N.; GUREV, A.; LUPASCU, G.; GORINCIOI, E. Iridoid glycosides from Linaria genistifilia (L.) Mill. ln biological control of soil-borne fungal pathogens of wheat and some structure consideration. Chemistry Journal of Moldova. General, Industrial and Ecological Chemistry. 2015, 10 (1), 57-63. ISSN (p) 1857-1727, ISSN (e) 2345-1688 (IF: 0.135).
5.    HUDZ N., IVANOVA R., BRINDZA J., GRIGORIEVA O., SCHUBERTOVA Z., IVANISOVA E. Approaches to the determination of antioxidant activity of extracts from bee bread and safflower leaves and flowers. Slovak Journal of Food Sciences „Potravinarstvo“, 2017, 11(1), 480-488. ISSN 1337-0960. DOI: 10.5219/786
6.    МАЩЕНКО, Н.Е.; БОРОВСКАЯ, А.Д.; ГУМАНЮК, А.В.; БАЛАШОВА, И.Т.; КОЗАРЬ, Е.Г. Эффективность действия регуляторов природного происхождения при выращивании моркови. Овощи России. М., 2018, №1, 74-78. ISSN 2072-9146.
7.    БОРОВСКАЯ А.Д. МАЩЕНКО Н.А. ГУМАНЮК А.В. Вторичные метаболиты высших растений как регуляторы роста для лука репчатого. Овощи России. М., 2018, №4, 71-75. ISSN 2072-9146.
8.    ELISOVETCAIA, D.; IVANOVA, R.; BRINDZA, J. Insecticidal and antifeedant activity of the ethanolic extracts from Allium rotundum L. AGROFOR, 2018, 3(2), 114-120. ISSN 2490-3434 (Printed), ISSN 2490-3442 (Online) DOI:10.7251/AGRENG1802114E
9.    BOROVSKAIA, А.; MASCENCO, N.; IVANOVA, R.;  SPAK, L. Impact of plants secondary metabolites on cabbage productivity (Действие  вторичных метаболитов  растений на продуктивность капусты белокочанной). Scientific Proceedings “Agrobiodiversity for improving nutrition, health and life quality”, Nitra, Slovakia 2019, 3, 241-248.  ISSN 2585-8246; ISBN 978-80-552-2108-3. DOI: 10.15414/agrobiodiversity.2019.2585-8246.241-248
10.    GUREV, A.; MASCENKO, N.; BOROVSKAIA, A.; SUBINA, V. Research of biologically active substances from Linaria genistifolia (L.) Mill and their potential usage in the ecological agriculture. Journal of Engineering Science, Chisinau: UTM.  2019, 24(2), p. 109-116. ISSN 2587-3474, eISSN 2587-3482. file:///C:/Users/37379/AppData/Local/Temp/Gurev-A-JES-2019-2_pp-109-116.pdf
11.    IVANOVA, R. Antiradical capacity of seed extracts evaluated by potentiometric procedure. In book: “Agrobiodiversity for Improving Nutrition, Health and Life Quality, 2016”, Nitra: Ed. Agrobiodiversity, Slovakia. pp. 140-144. ISBN 978-80-552-1586-0.
12.    МАЩЕНКО, Н.Е.; БОРОВСКАЯ, А.Д.; ГУМАНЮК, А.В. Препараты на основе стероидных гликозидов как регуляторы роста овощных культур. Биологически активные препараты для растениеводства. Научное обоснование – рекомендации – практические результаты = Biologically active preparations for plant growing. Scientific background – Recommendations – Practical results: материалы XIV Междунар. науч.-практ. конф., Минск, 3–8 июля 2018 г. / редкол.: Д. В. Маслак (отв. ред.) [и др.].  Минск: БГУ, 2018. с.137-139. ISBN 978-985-566-566-4.
13.    ELISOVETCAIA, D.; IVANOVA, R.; CASIAN, I.; CASIAN, A.; BRINDZA, J. Ethanolic extract and essential oils from Monarda fistulosa l. With ovicidal, insecticidal and antifeedant activity against Colorado potato beetle. Lucrări științifice. Seria Agronomie. Iaşi:”Ion Ionescu de la Brad”, Romania, 2018, 61(2), 69-72. ISSN 1454-7414.
14.    ELISOVETCAIA, D.; IVANOVA, R.; GLADEI, D.; SIMKOVA, J.; BRINDZA, J. Biological activity of extracts from some species of Coniferous plants. Scientific Proceedings “Agrobiodiversity for improving nutrition, health and life quality”, Nitra, Slovakia, 2019, 3, 66-80. ISSN 2585-8246; ISBN 978-80-552-2108-3. DOI: 10.15414/agrobiodiversity.2019.2585-8246.066-080
15.    IVANOVA, R.; ELISOVETCAIA, D.; TATAROV, P. Vegetal oils: do they have antioxidant activity? Book of proceedings. X International Scientific Agriculture Symposium "Agrosym 2019", Jahorina, October 03 - 06, 2019, East Sarajevo: Faculty of Agriculture, 2019, 843-849. ISBN 978-99976-787-2-0.  
16.    БОРОВСКАЯ, А.Д.; МАЩЕНКО, Н.Е.; ГУРЕВ А.С.; ИВАНОВА, Р.А. Применение ростовых веществ в инкрустации семян кукурузы. Materialele conferinței științifico-practice internașionale ”Aspecte inovative în ameliorarea culturilor agricole”, Paşcani, 6-7 septembrie 2018. Chișinău: Print Caro. 2018. P. 87-92.  ISBN 978-9975-56-560-8.
17.    ЕЛИСОВЕЦКАЯ, Д.С.; ИВАНОВА, Р.А.; МАЩЕНКО, Н.Е. Применение растительных экстрактов в качестве биорегуляторов и биопестицидов на картофеле. Доклады Международной научно-практической конференции «Селекция, семеноводство и технологии возделывания сельскохозяйственных культур», посвященной 90-летию со дня основания института, Приднестровский НИИ сельского хозяйства, 10 апреля 2020 / отв. ред.: А. В. Гуманюк. - Тирасполь: Eco-TIRAS, 2020 (Tipogr. ”Arconteh”), с. 271-274. ISBN 978-9975-3404-1-0.
18.    Recomandări cu privire la aplicarea regulatorilor naturali de creştere la cultivarea legumelor. Resp. ed.: Vasile Botnari., Chişinău : S. n., 2017 (Tipogr. "MS Logo"). – 24 p. ISBN 978-9975-3175-1-1.
19.    Recomandări cu privire la aplicarea regulatorilor naturali de creştere la cultivarea cerealelor.  Resp. ed.: Vasile Botnari., Chişinău : S. n., 2017 (Tipogr. "MS Logo"). 16 p. ISBN 978-9975-3175-3-5.
20.    МАЩЕНКО, Н.Е.; БОРОВСКАЯ, А.Д.; ШУБИНА, В.Е.; ИВАНОВА, Р.А.; ГУМАНЮК, А.В.; ШПАК, Л.И. Применение биорегуляторов растительного происхождения в технологии возделывания овощных культур. Рекомендации подготовлены на основе материалов совместных исследований сотрудников Института генетики, физиологии и защиты растений и Приднестровского научно-исследовательского института сельского хозяйства. Chisinău, 2019,  20 с.



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